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What Dr. Chatbot ordered

The ideas and innovators shaping health care
Feb 16, 2023 View in browser
 
Future Pulse

By Ben Leonard, Ruth Reader, Carmen Paun and Erin Schumaker

TECH MAZE

LONDON, ENGLAND - FEBRUARY 03: In this photo illustration, the OpenAI

The chatbot ChatGPT has already passed medical exams. | Getty Images

Your doctor could be a robot sooner than you think.

The pandemic and its toll on the health care sector spurred interest in the role artificial intelligence can play in easing burdens and improving efficiency, particularly via chatbots to tackle routine tasks like scheduling appointments and billing issues.

But evidence is building that suggests chatbots are already pretty good at giving health advice.

Most recently, researchers from the Cleveland Clinic and Stanford University asked ChatGPT, the robot brain developed by the firm OpenAI, 25 questions about heart disease prevention.

The online oracle’s answers earned a solid B, hitting the mark on 21 of the questions — 84 percent, according to a human reviewer.

ChatGPT’s responses were appropriate for a broad range of recommendations, including questions about how to lose weight and lower cholesterol and the meaning of certain coronary calcium scores.

“That surprised us and suggested that the way it was trained, it was able to pick up even nuanced information, presumably from the internet, and condense it into fairly simple responses,” Ashish Sarraju, a cardiologist at the Cleveland Clinic, told Ben.

But the algorithm struck out on some other nuanced questions, like those about exercise. It “firmly recommended” cardio and weightlifting, which could harm some patients. It also missed key details on questions about cholesterol levels, and it incorrectly suggested that a cardiovascular disease drug isn’t commercially available.

“When it comes to sophisticated medical decision-making, it fell behind a little bit,” Sarraju said, adding that clinical experts and patients should be involved in training chatbots to improve them.

Other recent research found sometimes-contradictory evidence of chatbots’ smarts or lack thereof:

— They have significant promise in health care but are in the early stages of development and need to be researched more, according to a 2022 review in Nature. Twenty-three percent of chatbot apps reviewed gave information about a specific health area, with some providing mental health counseling. Less than 1 in 10 had a “theoretical or therapeutic framework” like cognitive behavioral therapy.

“It seems like they’re the next frontier,” corresponding author Smisha Agarwal, director of the Center for Global Digital Health Innovation at Johns Hopkins University, said. “[But] evidence-based treatment modalities do need to be incorporated, best practices within the field need to be incorporated, and they're often not.”

— They have “no statistically significant effect” on “subjective wellbeing,” according to a 2020 review in the Journal of Medical Internet Medicine, which also found “weak evidence” of effectiveness in treating mental health issues like stress and depression.

— They suffer from a “black box” problem in which it’s difficult to understand how they came to a certain answer, “potentially undermining the shared decision-making between physicians and patients,” 2021 research in JMIR Cancer found. Chatbots can be integrated into care to reduce costs and bolster outcomes, but even so, “human elements” aren’t replaceable, the authors concluded. Still, chatbots are “likely to be a key player” in improving cancer care in part by learning from large datasets.

— They can be helpful for mental health care and substance use disorder, according to some evidence in smaller studies on the chatbot WoeBot. Those studies were conducted by researchers from Stanford and WoeBot’s makers. The company commissioned a survey that found close to three-quarters of Americans would be interested in chatbots “if they were scientifically proven” to work well.

 

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WELCOME TO FUTURE PULSE

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This is where we explore the ideas and innovators shaping health care.

In news most of you probably didn’t want to hear, researchers have found that despite not having external ears, snakes are able to hear better than you’d expect.

Share any thoughts, news, tips and feedback with Ben Leonard at bleonard@politico.com, Ruth Reader at rreader@politico.com, Carmen Paun at cpaun@politico.com or Erin Schumaker at eschumaker@politico.com.

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Today on our Pulse Check podcast, your host Ruth talks with Erin about the prospect of developing next-generation non-hallucinogenic versions of drugs like psilocybin to treat brain disorders, such as depression, post-traumatic stress disorder and addiction, and the regulatory barriers researchers who want to study psychedelics are up against.

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CHECKUP

Ronan Kotiya, 11, right holds his father Rupesh Kotiya's ventilator tube as his mother works to clean his tracheotomy tube at their home in Plano, Texas, Sunday, April 10, 2022. Ronan helps care for his father who suffers from Lou Gehrig's disease that requires a ventilator and around the clock care. Millions of Americans with serious health problems depend on children ages 18 and younger to provide some or all of their care at home. An exact number is hard to pin   down, but researchers think millions of children are involved in caregiving in the U.S. (AP Photo/LM Otero)

Researchers believe that analyzing changes in speech patterns could help diagnose ALS earlier. | AP

There’s no cure for Lou Gehrig’s disease, but catching it early and beginning treatment can improve patients’ quality of life and delay symptom onset.

Researchers at MIT, Massachusetts General Hospital, Temple University and IBM are trying to figure out whether they can catch the disease in its early stages by analyzing patients’ speech patterns.

The disease, also known as amyotrophic lateral sclerosis, or ALS, is hard to diagnose early because its principal symptom, loss of muscle control, is similar to those of other conditions.

The researchers, in collaboration with startup EverythingALS, a nonprofit seeking to use data to find new ALS treatments, are embarking on a study to validate algorithms that can detect signs of ALS and also measure disease progression using speech. A thousand participants have enrolled so far.

“Even if someone says they don’t have changes in their speech, our algorithm can detect a change,” said Kely Norel, a digital health researcher at IBM Research.

To obtain a speech sample, a doctor asks a participant to describe their day.

The researchers hope that a neurologist, or even a general practitioner, could deploy this simple screening method if the analysis works.

In the more immediate term, Norel said, speech analysis could be used to help select patients for clinical trials.

This forthcoming study builds on past research that showed promise for using speech to detect early signs of cognitive decline in patients with ALS.

 

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IN THE COURTS

Social Media apps on a phone

A lawsuit contends that social media causes mental illness. | Oli Scarff/AFP/Getty Images

Lawyers for families who believe their children’s mental illnesses were caused by social media filed a consolidated complaint against America’s tech giants in federal district court in San Francisco on Wednesday.

Opening argument: The lawsuit claims that social media is a defective product governed by existing product liability law. It claims the companies knowingly created and unleashed algorithms to recommend content designed to trigger compulsive use. Addicted users have suffered mental illness and, in some cases, death, the suit contends.

The lawsuit cites documents from whistleblower Frances Haugen, detailed in 2001 Senate testimony, that her former employer, Facebook, knew its Instragram site caused depression, anxiety and eating disorders in some minors. The suit also cites academic research buttressing that claim.

For the defense: The defendants, including Facebook and Google, say they’ve gone to great lengths to protect children online.

“We have invested heavily in creating safe experiences for children across our platforms and have introduced strong protections and dedicated features to prioritize their well-being,” said José Castañeda, a spokesperson for Google.

Meta, the parent company of Facebook and Instagram, says it uses artificial intelligence to determine whether someone is an adult and has introduced other methods of assessing age, including requiring an ID or selfie when the platform believes someone is misrepresenting themselves.

Instagram has 30 features aimed at making it safer for minors to use. The site shows them no alcohol or weight-loss advertisements.

Meta also has supervision tools that let parents monitor their children’s social media accounts.

 

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